The Crystal Structure of Orotic Acid Monohydrate (Vitamin B13)

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A possible relationship of vitamin B13 to orotic acid.

Novak, Hauge, and Carrick (1) presented evidence that one or more unidentified chick growth factors were present in distillers’ dried solubles (DDS). Novak and Hauge (2) announced the isolation of an unknown growth factor in a relatively high degree of purity from DDS. This substance was very potent in stimulating rat growth and was designated vitamin B13. It has an ultraviolet absorption maxim...

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Redetermination of orotic acid monohydrate

The crystal structure of the title compound, which is also known as vitamin B(13) (systematic name: 2,6-dioxo-1,2,3,6-tetra-hydro-pyrimidine-4-carboxylic acid monohydrate), C(5)H(4)N(2)O(4)·H(2)O, was reported for the first time by Takusagawa & Shimada [Bull. Chem. Soc. Jpn (1973 ▶), 46, 2011-2019]. The present redetermination provides more precise values of the mol-ecular geometry. The asymmet...

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In the title compound, C10H10N2O6·H2O, the carb-oxy-lic acid group and the nitro group are essentially coplanar with the benzene ring [maximum deviation = 0.0264 (9) Å], while the amide group is oriented at a dihedral angle of 9.22 (5)° with respect to the benzene ring. In the crystal, classical O-H⋯O and N-H⋯O hydrogen bonds and weak C-H⋯O inter-actions link the organic mol-ecules and water mo...

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ژورنال

عنوان ژورنال: Bulletin of the Chemical Society of Japan

سال: 1973

ISSN: 0009-2673,1348-0634

DOI: 10.1246/bcsj.46.2011